|
|
Table 1. Autoimmune diseases & the associated autoantibodies
|
Clinical Diagnosis |
Autoantigens |
Preffered tissue |
Lowest significant titre |
other relevant tests |
|
Addison's disease |
P450 enzymes |
adrenal gland |
1:5 |
ovarian, testis, GPC |
|
Churg-Strauss Syndrome |
P-ANCA |
neutrophils |
1:20 |
ANA, CRP |
|
Coeliac disease |
endomysium |
monkey oesophagus |
1:10 |
gliadin & reticulin |
|
Crohn's Disease |
P-ANCA pacreatic acinar cells |
neutrophils pancreas |
1:20 |
CRP |
|
Dermatitis herpetiformis |
endomysial abs. |
monkey oesophagus |
1:10 |
gliadin & reticulin |
|
Diabetes Mellitus |
islet cells, glutamic acid decarboxylase |
monkey / human pancreas |
1:5 |
|
|
Gastritis (autoimmune) |
parietal cells |
stomach fundus |
1:20 |
thyroid antibodis |
|
Goodpasture's syndrome |
glomerular basement membrane |
monkey kidney |
1:5 |
ANCA, CRP |
|
Hepatitis: infectious; drug induced; autoimmune |
Liver/Kidney/microsomes smooth muscle |
rat liver/kidney |
1:20 |
mitochondrial, ANA, dsDNA, liver membrane abs, ANCA |
|
Herpes gestationis |
epidermal basement membrane zone |
monkey oesophagus |
1:10 |
skin biopsy for IgG or C3/C9 |
|
Idiopathic cresc. glom'nephritis |
P-ANCA |
neutrophils |
1:20 |
ANA, CRP |
|
lug carcinoma |
ANNA |
cerebellum |
1:100 |
striated muscle, ANA |
|
Microscopic polyangiitis |
P-ANCA |
neutrophils |
1:20 |
ANA, CRP, myeloperoxydase |
|
Myaesthenia gravis |
sarcomere |
skeletal muscle |
1:5 |
acetylcholine receptor abs. |
|
Myocarditis |
myosin, tropomyosin, etc |
monkey heart |
1:5 |
|
|
Ovarian failure / infertility |
P450 enzymes |
ovary, adrenal, testis |
1:5 |
thyroid |
|
Ovary / breast carcinoma |
Purkinje cells |
cerebellum |
1:100 |
|
|
Pemphigoid (bullous) |
epidermal basement membrane zone |
monkey oesophagus |
1:20 |
skin biopsy for IgG or C3/C9 |
|
Pemphigoid (cicatricial) |
epidermal basement membrane zone |
monkey oesophagus |
1:20 |
skin biopsy for IgG or C3/C9 |
|
Pemphigus |
epidermal intra-cellular proteins |
monkey oesophagus |
1:20 |
direct If on patient's skin |
|
Pernicious anaemia |
parietal cells |
stomach fundus |
1:20 |
thyroid antibodies |
|
Polyarteritis nodosa |
C-ANCA |
neutrophils |
1:20 |
ANA |
|
Primary biliary cirrhosis |
mitochondria |
liver, kidney, stomach |
1:20 |
ASM, CRP |
|
Primary sclerosing cholangitis |
P-ANCA |
neutrophils |
1:20 |
CRP |
|
Rheumatoid arthritis |
granulocytes aspecific ANA |
neutrophils |
1:20 |
rheumatoid factor ANA |
|
Stiff-man syndrome |
glutamic acid |
monkey pancreas |
1:5 |
western blot |
|
Thymoma |
skeletal muscle |
skeletal muscle |
1:5 |
acetylcholin receptor abs |
|
Thyroid diseases-all types |
thyroglobulin, peroxydase |
monkey thyroid |
1:20 |
GPC, islet cell abs, steroid cells abs, EIA for thyroid antibodies |
|
Tubulo intersitial nephritis |
tubule basement membrane |
kidney |
1:20 |
|
|
Ulcerativ colitis |
P-ANCA |
neutrophils |
1:20 |
CRP |
|
Wegener's granulomatosis |
P-ANCA C-ANCA |
neutrophils |
1:20 |
ANA |
